Yukihiro Saito Selected Research

MAP-kinase-activated kinase 3

1/2020	Development of gene therapy with a cyclic adenosine monophosphate response element decoy oligodeoxynucleotide to prevent vascular intimal hyperplasia.
1/2013	Cyclic adenosine monophosphate response-element binding protein activation by mitogen-activated protein kinase-activated protein kinase 3 and four-and-a-half LIM domains 5 plays a key role for vein graft intimal hyperplasia.

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Yukihiro Saito Research Topics

Disease

4	Heart Failure 03/2022 - 08/2011
3	Hypertrophy 05/2019 - 08/2011
3	Fibrosis (Cirrhosis) 05/2019 - 01/2019
3	Pulmonary Arterial Hypertension 05/2015 - 01/2012
3	Hypoxia (Hypoxemia) 01/2015 - 11/2007
2	Aortic Valve Stenosis (Aortic Stenosis) 02/2021 - 01/2021
2	Chronic Limb-Threatening Ischemia 07/2020 - 01/2018
2	Hyperplasia 01/2020 - 01/2013
2	5 Familial Hemophagocytic Lymphohistiocytosis 01/2020 - 01/2013
2	Peripheral Arterial Disease 06/2019 - 10/2011
2	Cardiomegaly (Heart Hypertrophy) 05/2019 - 01/2019
2	Body Weight (Weight, Body) 05/2019 - 01/2019
2	Infections 05/2018 - 02/2018
2	Ischemia 10/2014 - 10/2011
2	Lymphedema (Milroy Disease) 01/2013 - 09/2006
1	Insulin Resistance 03/2022
1	Myocardial Ischemia (Ischemic Heart Diseases) 03/2022
1	Cardiotoxicity 01/2022
1	Amyloidosis 12/2021
1	Immunoglobulin Light-chain Amyloidosis 12/2021
1	Stroke (Strokes) 07/2020
1	Diabetes Mellitus 01/2020
1	Inflammation (Inflammations) 01/2019
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2019
1	Hypersensitivity (Allergy) 02/2018
1	Arteriosclerosis Obliterans 01/2018
1	Vascular Calcification 08/2017
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2017
1	Pulmonary Hypertension 05/2015
1	Right Ventricular Hypertrophy 05/2015
1	Neoplasms (Cancer) 01/2015
1	Catheter-Related Infections 01/2015
1	Vascular Remodeling 10/2007

Drug/Important Bio-Agent (IBA)

2	Sodium-Glucose Transporter 2 InhibitorsIBA 03/2022 - 05/2019
2	Sodium-Glucose Transport ProteinsIBA 03/2022 - 05/2019
2	Neprilysin (Neutral Endopeptidase)IBA 01/2022 - 01/2019
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2022 - 01/2019
2	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 01/2019
2	AntioxidantsIBA 01/2022 - 01/2019
2	Adenosine Monophosphate (AMP)IBA 01/2020 - 01/2013
2	MAP-kinase-activated kinase 3IBA 01/2020 - 01/2013
2	Mitogen-Activated Protein KinasesIBA 01/2020 - 01/2013
2	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2013
2	Interleukin-6 (Interleukin 6)IBA 05/2019 - 01/2019
2	Eicosapentaenoic AcidIBA 08/2017 - 01/2017
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2015 - 11/2007
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2013 - 09/2006
1	Glucose (Dextrose)FDA LinkGeneric 03/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	Proteins (Proteins, Gene)FDA Link 12/2021
1	Therapeutic UsesIBA 01/2020
1	OligodeoxyribonucleotidesIBA 01/2020
1	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2019
1	Natriuretic PeptidesIBA 05/2019
1	SaltsIBA 05/2019
1	Collagen Type IV (Type IV Collagen)IBA 05/2019
1	Pharmaceutical PreparationsIBA 05/2019
1	KetonesIBA 05/2019
1	6- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA 05/2019
1	sacubitrilIBA 01/2019
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2019
1	EndonucleasesIBA 01/2019
1	DNA Repair EnzymesIBA 01/2019
1	Angiotensin Receptor AntagonistsIBA 01/2019
1	Valsartan (Vals)FDA Link 01/2019
1	ChemokinesIBA 01/2019
1	Caspase 3 (Caspase-3)IBA 01/2019
1	MetalsIBA 02/2018
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2017
1	Imatinib Mesylate (Gleevec)FDA Link 05/2015
1	Platelet-Derived Growth FactorIBA 05/2015
1	MonocrotalineIBA 05/2015
1	MacrolidesIBA 01/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2015
1	RoxithromycinIBA 01/2015
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2015
1	Pioglitazone (Actos)FDA Link 10/2014
1	PPAR gammaIBA 10/2014
1	Carrier Proteins (Binding Protein)IBA 01/2013
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2012
1	Nicardipine (Dagan)FDA LinkGeneric 01/2012
1	Angiogenesis InhibitorsIBA 10/2011
1	Small Interfering RNA (siRNA)IBA 10/2011
1	ElementsIBA 10/2011
1	Bisoprolol (Concor)FDA LinkGeneric 08/2011
1	Carvedilol (Coreg)FDA LinkGeneric 08/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2011
1	Metoprolol (Toprol-XL)FDA LinkGeneric 08/2011
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2007
1	NF-kappa B (NF-kB)IBA 10/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2007

Therapy/Procedure

3	Therapeutics 07/2020 - 08/2011
2	Transcatheter Aortic Valve Replacement 02/2021 - 01/2021
1	Drug Therapy (Chemotherapy) 01/2022
1	Surgical Amputation (Amputations) 07/2020
1	Lasers (Laser) 06/2019
1	Artificial Pacemaker 05/2018
1	Limb Salvage 01/2018
1	Renal Dialysis (Hemodialysis) 01/2018
1	Intravenous Administration 01/2015